AI + MULTI-OMICS ➡ PRECISION ONCOLOGY
The Chiu Lab is an interdisciplinary team affiliated with the UPMC Hillman Cancer Center and Department of Medicine at the University of Pittsburgh. Our mission is to bridge cutting-edge computational algorithms to unmet needs in precision oncology. Read more about the PI.
Research highlights
DepLink: an R Shiny app that systematically links genetic and pharmacologic dependencies of cancer
DepLink is a web server to identify genetic and pharmacologic perturbations that induce similar effects on cell viability or molecular changes. It integrates heterogeneous datasets of genome-wide CRISPR loss-of-function screens, high-throughput pharmacologic screens, and gene expression signatures of perturbations. Check out the tool here!
BHI is the flagship conference of the IEEE-EMBS (IEEE Engineering in Medicine and Biology Society) and serve as a unique forum for informatics and computing in healthcare and life sciences. We are organizing the Educational Activities including tutorials and trainee travel awards. Stay tuned!
Extending in vitro CRISPR screens to in vivo applications
Our latest Science Advances paper presents a novel “transfer learning” scheme that integrates cancer multi-omics and extends in vitro genetic screens to impracticable-to-screen tumors. The study was highlighted by @NCIgenomics as the #1 paper of 2021. Read the article.
AI-based in silico drug screening
Accurate prediction of cancer cells’ response to treatments is a key towards precision oncology. We developed an innovative, accurate AI model that virtually screens for ~300 anti-cancer drugs. Our study was selected as Springer Nature Research Highlights in Genetics of 2019 and has been cited for 150+ times. Read the article.
News
9/2023. Dr. Chiu receives an Administrative Supplement award from the NIH Office of the Director to develop computational frameworks that enhance AI-readiness of multi-omics data!
7/2023. Dr. Chiu receives a two-year New Investigator Research Grant from the Leukemia Research Foundation to develop intelligent therapeutic strategies for acute myeloid leukemia.
7/2023. We will be presenting at ISMB/ECCB 2023 @ Lyon, France on our newest web server that predicts anti-cancer drug responses.
6/2023. DepLink has now been published in Bioinformatics Advances! Check out the paper and tool. Kudos to Tapsya and Li-Ju!
4/2023. Dr. Chiu receives the Pittsburgh Liver Research Center (PLRC) Pilot & Feasibility Grant to team up with Dr. Paul Monga to study and predict drug responses of hepatocellular carcinoma.
1/2023. Dr. Chiu receives a pilot award from the UPMC Hillman Cancer Center Developmental Pilot Program with Dr. Yu-Chih Chen (MPI) to implement an intelligent drug screening device for single cancer cells.
More News
5/2023. We will be presenting at GLBIO 2023 @ Montreal, Canada. Dr. Chiu is giving a talk about our newest web tool DepLink, which systematically links genetic vulnerabilities to drug responses using high-throughput screening data.
4/2023. We will be presenting at AACR 2023 @ Orlando, FL. Come to check out our poster #2094 and #3175.
2/2023. We will be presenting at San Antonio Pediatric Cancer Symposium @ San Antonio, TX.
12/2022. We will be presenting at AACR-JCA Joint Conference 2022 @ Maui, HI.
11/2022. Dr. Chiu is invited to present in the "BHI Technical and Educational Lecture" organized by the IEEE EMBS Community on Biomedical & Health Informatics (BHI).
9/2022. Dr. Chiu is selected as the "2022 Hillman Early Career Fellow for Innovative Cancer Research" by the Hillman Foundation.
8/2022. We will be presenting at ICIBM 2022 @ Philadelphia, PA. Dr. Chiu is co-chairing the session “Artificial Intelligence on Big Data: Promise for Early-stage Trainees.”
7/2022. We will be presenting at ISMB 2022 @ Madison, WI.
7/2022. Grand Opening of our lab at Pitt!
Visit us
Our lab is located at The Assembly – where history, innovation, technology, and medicine meet!