The Chiu Lab is an interdisciplinary team affiliated with the UPMC Hillman Cancer Center and Department of Medicine at the University of Pittsburgh. Our mission is to bridge cutting-edge computational algorithms to unmet needs in precision oncology. Read more about the PI.

Research highlights

DepLink: an R Shiny app that systematically links genetic and pharmacologic dependencies of cancer

DepLink is a web server to identify genetic and pharmacologic perturbations that induce similar effects on cell viability or molecular changes. It integrates heterogeneous datasets of genome-wide CRISPR loss-of-function screens, high-throughput pharmacologic screens, and gene expression signatures of perturbations. Check out the tool here!

BHI is the flagship conference of the IEEE-EMBS (IEEE Engineering in Medicine and Biology Society) and serve as a unique forum for informatics and computing in healthcare and life sciences. We are organizing the Educational Activities including tutorials and trainee travel awards. Stay tuned!

Extending in vitro CRISPR screens to in vivo applications 

Our latest Science Advances paper presents a novel “transfer learning” scheme that integrates cancer multi-omics and extends in vitro genetic screens to impracticable-to-screen tumors. The study was highlighted by @NCIgenomics as the #1 paper of 2021. Read the article.

AI-based in silico drug screening 

Accurate prediction of cancer cells’ response to treatments is a key towards precision oncology. We developed an innovative, accurate AI model that virtually screens for ~300 anti-cancer drugs. Our study was selected as Springer Nature Research Highlights in Genetics of 2019 and has been cited for 150+ times. Read the article.


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